3- Heat intolerance & xerostomia
4-Characteristic face :frontal bossing, abscense of eye brows & eyelashes ,saddle nose. prominent lips &large ears.
5-multiple congenital absence of teeth.
6-reduced facial vertical height(lack of alveolar growth)
7- maxillary hypoplasia
8-small and conical anterior teeth ,often with large diastemia
9- family history of similar condition