How can you know for sure if it’s your liver that’s ailing you? Severe fatigue, digestive disturbances, swelling, a constant chilled feeling and poor appetite—all these can be symptoms of liver dysfunction. Another sign is the inability to tolerate medications. Your liver plays an important role in ****bolizing the chemical compounds in many pre******ion and over-the-counter drugs. Notice how many of the printed inserts and advertising for common medications include the warning about the potential effect on the liver.