Interesting that your doctor put you on the combo estro/progesterone. The first time I started on hrt, the endocrinologist put me on an estradiol birthcontrol pill, three weeks on/one week off but no Spiro. I ended up having a bad reaction and had to quite. There was no proof but my cholesterol being too high probably had something to do with it, so it's a good thing your doctor made you get yours down first. I'm on the EV shots now with Spiro and I hit the magic sweet spot with hormone levels after only 5 wks and haven't looked back since.