In congenital heart disease (CHD), anatomical anomalies of the heart are generally associated with abnormal hemodynamicload and neurohumoral activation as Brain Natriuretic Peptide (BNP) and its N-terminal prohormone fragment (NTproBNP) found in the circulation are mainly expressed by ventricular cardiac myocytes in response to ventricular volume and pressure overload.(6,7) )