Skip-Bo is a fast-paced card game in which players race to get rid of their own cards while blocking their opponents' opportunities to do the same. To play, you'll need a deck of Skip-Bo cards and at least two players, although you can play with up to six. The deck consists of 162 cards: 12 sets of 12 numbered cards and 18 Skip-Bo wild cards. The game is a variation on traditional card game Spite and Malice, which has similar rules but uses an ordinary playing card deck.
Read more : http://www.ehow.com/how_2062678_play-skipbo.html