Number of tablets, any concomitant tablets (include herbal medicine, such as St John's wort - an enzyme inducer).
•Time of overdose.
•Suicide risk - was a note left?
•Any alcohol taken (acute alcohol ingestion will inhibit liver enzymes and may reduce the production of the toxin NAPQI, whereas chronic alcoholism may increase it).
Examination
•If ALF develops, the following may be seen: jaundice, hepatic flap, encephalopathy and tender hepatomegaly.